Skip to main
Tesamorelin Reviews

A holographic research console on tesamorelin — every peer-reviewed trial on the GHRH analogue read as a panel, with the FDA scope, the IGF-1 cautions and the honest data gaps surfaced first.

Papers behind these notes 07

Tesamorelin references name every paper used

Each numbered mark leads to the medical paper that supports the sentence.

Return to trial findingsOpen the short answers

Published papers support the tesamorelin findings

You may keep health papers in a drawer for later. The list below serves the same purpose. These papers report what doctors found in tesamorelin trials.

Some papers cover the final large tests before approval, called Phase 3 trials. Others report belly scans, liver scans, and blood tests. Every dose and percentage comes from those papers.

The numbered mark after a sentence points to one paper. You can check the authors, date, and journal below. The full list of cited references comes next.

  1. Falutz J, Allas S, Blot K, Potvin D, Kotler D, Somero M, Berger D, et al. Metabolic effects of a growth hormone-releasing factor in patients with HIV. N Engl J Med. 2007;357(23):2359-2370. ↗
  2. Falutz J, Allas S, Mamputu JC, Potvin D, Kotler D, Somero M, Berger D, Brown S, Richmond G, Fessel J, Turner R, Grinspoon S. Long-term safety and effects of tesamorelin, a growth hormone-releasing factor analogue, in HIV patients with abdominal fat accumulation. AIDS. 2008;22(14):1719-1728. ↗
  3. Tesamorelin: chemical and pharmacologic profile — a synthetic GHRH(1-44) analogue with an N-terminal trans-3-hexenoyl modification conferring DPP-IV resistance (CAS 218949-48-5; FDA UNII 9MM72X02HA; ATC H01AC06; MW 5135.9 Da). DrugBank DB08869. ↗
  4. Stanley TL, Chen CY, Branch KL, Makimura H, Grinspoon SK. Effects of a growth hormone-releasing hormone analog on endogenous GH pulsatility and insulin sensitivity in healthy men. J Clin Endocrinol Metab. 2011;96(1):150-158. ↗
  5. Tesamorelin — LiverTox: Clinical and Research Information on Drug-Induced Liver Injury. National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK). 2018. Notes 2010 U.S. approval (NDA 022505) for HIV-associated lipodystrophy; likelihood score E; labeled contraindications (active malignancy, hypersensitivity, pregnancy). ↗
  6. Stanley TL, Feldpausch MN, Oh J, Branch KL, Lee H, Torriani M, Grinspoon SK. Effect of tesamorelin on visceral fat and liver fat in HIV-infected patients with abdominal fat accumulation: a randomized clinical trial. JAMA. 2014;312(4):380-389. ↗
  7. Stanley TL, Fourman LT, Feldpausch MN, Purdy J, Zheng I, Pan CS, et al. Effects of tesamorelin on non-alcoholic fatty liver disease in HIV: a randomised, double-blind, multicentre trial. Lancet HIV. 2019;6(12):e821-e830. ↗
  8. Badran AS, et al. Body composition, hepatic fat, metabolic, and safety outcomes of tesamorelin, a GHRH analogue, in HIV-associated lipodystrophy: a meta-analysis of randomized controlled trials. Obes Res Clin Pract. 2026. ↗
  9. Russo SC, Ockene MW, Arpante AK, Johnson JE, Lee H, Toribio M, Stanley TL, Hadigan CM, Grinspoon SK, Erlandson KM, Fourman LT. Efficacy and safety of tesamorelin in people with HIV on integrase inhibitors. AIDS. 2024. ↗
  10. Ellis RJ, Vaida F, Hu K, Dube MP, Henry B, Chow F, Heaton RK, Lee D, Sattler F. Effects of tesamorelin on neurocognitive impairment in persons with HIV and abdominal obesity. J Infect Dis. 2025. ↗
  11. Mayfield CK, et al. Injectable peptide therapy: a primer for orthopaedic and sports medicine physicians. Am J Sports Med. 2026. ↗
  12. Gonzalez-Sales M, et al. Population pharmacokinetic analysis of tesamorelin — apparent plasma clearance ~1,060 L/h with no clinically relevant demographic covariates and a ~13% increase in absorbed fraction by day 14 versus day 1. 2015. ↗
  13. Gattu AK, Fourman LT. Metabolic dysfunction-associated steatotic liver disease in people with HIV. Curr Opin HIV AIDS. 2025. ↗
  14. Yen DW, Sherman KE. Causes and outcomes of hepatic fibrosis in persons living with HIV. Curr Opin HIV AIDS. 2022;17:359-367. ↗